iPSC Cardiomyocytes for Chemical Hazard Prioritization
2026-08-29
Tsai and colleagues developed an integrated screening strategy that combines functional phenotypes, cytotoxicity, and transcriptomic responses in human iPSC-derived cardiomyocytes across 464 environmental chemicals and pharmaceuticals. The study shows that phenotype- and transcriptome-derived points of departure can support complementary hazard interpretation and exposure-based prioritization rather than relying on electrophysiology alone.
SETD7 Depletion Promotes White Adipose Browning
2026-08-29
The reference study identifies SETD7 as a negative regulator of inguinal white adipose tissue thermogenesis. Using genetic, cellular, metabolic, and transcriptomic approaches, the authors show that SETD7 depletion increases the Adcy7–Sirt1–CREB1 axis, enhances beige adipocyte activity, and protects obese mice from diet-induced metabolic deterioration.
Tranexamic Acid Workflows for Clot Stability
2026-08-28
Tranexamic Acid provides a practical way to model inhibition of fibrinolysis, from plasmin assays to clot-stability and cell-adherence workflows. This guide translates the compound’s antifibrinolytic mechanism into reproducible bench experiments and shows how the same design logic supports advanced wound-dressing research.
Moxidectin for Antifungal Synergy Workflows
2026-08-28
Moxidectin is best known as a macrocyclic lactone anthelmintic, yet recent research positions it as a mechanistically distinctive potentiator for polyene activity against Candida albicans. This guide translates that finding into practical microdilution, biofilm, sterol-analysis, and translational workflows while separating established veterinary use from exploratory antifungal research.
Golgi-Tracker Green: From Signal to Mechanism
2026-08-27
Golgi-Tracker Green enables live-cell Golgi apparatus labeling with a BODIPY FL-labeled C5-ceramide design. This article presents an assay framework for connecting Golgi morphology, lipid trafficking, and mechanistic findings in cancer-cell studies without confusing correlation with causation.
Macrophage EV miR-660 in Breast Cancer Metastasis
2026-08-27
The reference study identifies a macrophage-to-tumor communication mechanism in which extracellular vesicles transfer miR-660 to breast cancer cells and activate the KLHL21/IKKβ/NF-κB p65 axis. Its combined tissue, cell, extracellular-vesicle, and mouse-model evidence links this pathway to invasion and metastatic progression while highlighting experimental points for studying tumor microenvironment signaling.
FLCN Mutations and mRNA Rescue in BHD Syndrome
2026-08-26
A 2026 study identified the novel FLCN nonsense variant p.Q44* and supplied segregation and functional evidence supporting pathogenic reclassification of p.W376R in two Chinese Birt-Hogg-Dubé families. In HEK293T cells, synthetic FLCN mRNA restored folliculin expression and reduced abnormal mTORC1 signaling, providing an early in vitro rationale for protein-replacement research rather than a validated clinical therapy.
SU 5402: From RTK Biology to Translational Models
2026-08-26
SU 5402 is more than a receptor tyrosine kinase inhibitor: it is a strategic perturbation tool for connecting pathway activity with phenotype. This article examines its mechanistic value in cancer biology and multiple myeloma research, then defines the evidence required before extending RTK studies into human iPSC-derived sensory neuron models of HSV-1 latency.
HRP Goat Anti-Rabbit IgG (H+L) Antibody
2026-08-25
HRP Goat Anti-Rabbit IgG (H+L) Antibody provides an HRP-linked detection layer for rabbit primary antibodies in Western blotting, ELISA, IHC, and IC workflows. It is intended for research assay development and optimization, not diagnostic or medical use, and the supplied dossier does not establish assay-specific dilution, incubation, or performance values.
PPACK Dihydrochloride: Mapping Thrombin Control
2026-08-25
PPACK Dihydrochloride provides a high-affinity, irreversible thrombin clamp for dissecting platelet and coagulation phenotypes. This article develops a pathway-aware assay framework that pairs thrombin inhibition with insights from selective P2X1 blockade.
EdU Flow Cytometry Assay Kits (Cy5)
2026-08-24
EdU Flow Cytometry Assay Kits (Cy5) measure S-phase DNA synthesis through copper-catalyzed azide-alkyne cycloaddition (CuAAC) and Cy5 fluorescence. The K1078 workflow provides a DNA synthesis endpoint for flow cytometry cell proliferation assays while avoiding harsh DNA denaturation.
DED Assembly and Caspase-8 Signaling in Apoptosis
2026-08-23
The 2024 Nature Communications study resolves atomic-level FADD–procaspase-8–cFLIP assemblies using X-ray crystallography and cryo-electron microscopy. Its structural and mutational evidence explains how limited caspase-8 activation can support survival while coordinating apoptotic and necroptotic signaling through RIPK1.
Lovastatin: A Mechanism-First Assay Guide
2026-08-22
Lovastatin is an HMG-CoA reductase inhibitor with effects that extend from cholesterol biosynthesis to proliferation, apoptosis, macrophage efferocytosis, and tissue remodeling. This mechanism-first guide connects those endpoints with a plant-development study to improve assay design without overstating cross-domain evidence.
CDK4/6–BET Synergy in Pancreatic Cancer
2026-08-21
Gu et al. show that combining the CDK4/6 inhibitor palbociclib with the BET inhibitor JQ1 suppresses pancreatic ductal adenocarcinoma more effectively than either agent alone. The study is especially informative because it explains how BET inhibition counteracts CDK4/6 inhibitor-associated epithelial-to-mesenchymal transition through GSK3β-mediated Wnt/β-catenin and TGF-β/Smad signaling.
CHI3L1-IN-5 Workflow for Neuroinflammation
2026-08-20
Build a translational workflow around CHI3L1-IN-5 (Compound Z17) by connecting target-pathway readouts with astrocyte Aβ uptake and lysosomal assays. The guide also separates this CNS application from an independently reported ALDH2 activator that shares the Z17 designation, preventing a common interpretation error.
462 records 7/31 page Previous Next First page 上5页 678910 下5页 Last page